PubMed · 5191387
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
W M Politzer. 1968. Routine urinalysis.. https://pubmed.ncbi.nlm.nih.gov/5191387/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Explore the source record for details and available documents.
The nuclear magnetic resonance (NMR) powder patterns observed for the 31P spin pair in Lawesson's reagent (1) were analyzed. Using an efficient procedure, wide ranges of the spin parameters were examined to determine whether they might reproduce the experimental one-dimensional (1D) spectrum of the present A2 spin system. It was demonstrated that the parameters were not uniquely determined from the 1D powder pattern only, but a significant reduction of their uncertainties was realized using the two-dimensional (2D) powder pattern. The molecular structure of 1 was discussed in terms of the refined spin parameters.
A "phosphorothioate triester method" was investigated for the solution-phase synthesis of phosphorothioate oligonucleosides. Using fully protected 3'-phosphorothiolate thymidine bearing O-cyanoethyl and S-2,4-dichlorobenzyl groups as phosphorothioate protecting groups, decathymidine nonaphosphorothioate was efficiently assembled through a blockwise procedure. Two side reactions occurred during the deprotection steps: breakage of internucleoside linkages (1.8% per linkage) and formation of phosphate diester linkages (0.9%). Substitution of the dichlorobenzyl group by the more labile 4-nitrobenzyl S-protecting group reduced the extent of internucleoside bond breakage by one-half.