PubMed · 5236992
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G Frostell. 1967-11-15. [Harmless sweets--utopia or reality?].. https://pubmed.ncbi.nlm.nih.gov/5236992/
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This report summarizes the findings from eight individual remineralization studies that used the thin-section sandwich model. This model uses thin sections of human enamel (or dentin) containing caries-like lesions sandwiched between sheets of thin plastic which are then implanted into the buccal surfaces of molars in removable partial mandibular dentures. Toothbrushing with a sodium fluoride-positive control dentifrice for two-week periods always produced positive remineralization of the lesions, and similar use of a placebo always produced mean mineral loss. In most studies, the difference was significant at p less than 0.01. However, variation among specimens placed within an individual mouth were often large and even included cases where one lesion gained mineral while a closely adjacent lesion lost mineral. Similarly, mean mineral changes produced by an individual subject were not consistent from study to study and ranged from net demineralization in one study to net remineralization in another study. Nevertheless, mean mineral changes from all eight studies showed that all subjects produced more remineralization than demineralization when using a sodium fluoride-positive control dentifrice. Data are presented showing remineralization of thin-section lesions from a number of other fluoride and non-fluoride dentifrices and mouthrinses and showing that a product with reduced anti-caries activity (as measured by several tests) also resulted in reduced remineralization by the thin-section model.
Preventive cariology has primarily focused on the protection of teeth with fluorides and on oral hygiene. Another important preventive approach, namely diet modification reducing the frequency of consumption of acid-producing carbohydrates has not yet gained enough attention. It can very well be implemented by making available a wide variety of non- or hypo-acidogenic snacks. This paper presents a model system, the Swiss Sympadent Association, initiated and currently used in Switzerland for developing, testing, labelling and promoting "tooth-friendly" foods that do not give rise to intraplaque acid production. Based on the success of the Association in Switzerland, an international extension of this model is well on its way.
Previous plaque-pH telemetry studies reported the acidogenicity of various foods and dietary patterns to estimate potential cariogenicity. To avoid patient discomfort, improve compliance, and minimize electrode malfunctions, we have simplified our telemetry method and compared it to our previously published model. A removable partial prosthesis with a glass electrode set in the approximal space left by a missing first molar was used in 2 subjects. In the modified method, subjects suspended oral hygiene for 3 days, the prosthesis was then installed on the 3rd day, and accumulated plaque was spread on the electrode and covered with gauze for retention. In comparative tests, the same subjects wore the prosthesis in the mouth during plaque accumulation. Test sessions compared the plaque pH response to 4 treatments: a 10% sucrose rinse, a 10% sorbitol rinse, a snack roll with marmalade and coffee, and the snack followed by gum chewing. Overall, pH curves were similar (mean baselines and minimas) and no significant differences in mean pH response were noted between the 2 methods. The modified method improved subject participation, demonstrated greater reliability, and showed Stephan curves comparable to conventional methods.