PubMed · 529029
Nonlinear regression on multiple-dose data.
Abstract
The examples are given to show how Metzler's nonlinear regression program can be used to estimate parameters in a model with multiple dosing. The model of one example is a set of equations involving sums of exponentials, whereas the other model is a set of differential equations reflecting first order absorption and Michaelis-Menten excretion. In both cases no data were given in one of the dosing intervals.
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J R Howell. 1979. Nonlinear regression on multiple-dose data.. https://doi.org/10.1007/bf01061214
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