PubMed · 5452720
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G Cohen. 1970-09-10. [Isotope generators].. https://pubmed.ncbi.nlm.nih.gov/5452720/
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A reliable remote water target loading system has been designed and fabricated around the operation of a single pneumatic syringe dispenser that accesses one of two water reservoirs, filling one or more targets depending on the system configuration. For multiple radionuclide configuration, reservoirs are filled with 18O-enriched water for [18F]fluoride production, and natural abundance water for [13N]nitrate and [13N]nitrite production. When actuated, the system withdraws a calibrated volume of water from a selected reservoir, and automatically dispenses that charge through a short transfer line to the appropriate target. A second actuation then forces the dispenser to purge itself of residual water by dispensing a charge of helium gas through the same line thus completing the transfer of water to the target volume. Direct liquid level sensing inside the target, utilizing the specific resistance response of water, signals the operator that the target is loaded. For single radionuclide configuration, one or both reservoirs can be used with the same type of water, while dispensing is directed to a single target.
The production of 35.5-h 105Rh (560- and 250-keV betas) by neutron activation of 104Ru followed by beta decay of 4.4-h 105Ru is discussed. A simple procedure for producing 105Rh in 10-100 mCi quantities at specific activities of 700-10,000 Ci/mmol is described.
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