PubMed · 5603674
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J Fischer, R Wolf. 1967. [Quantitative determination of splenic function].. https://pubmed.ncbi.nlm.nih.gov/5603674/
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Using 51Cr, 125I, and 59Fe, red cell survival, blood volumes and certain aspects of iron metabolism were investigated in Sierra Leoneans referred for further evaluation of various blood disorders. The data provided clarification of the nature of the anaemia in some patients and demonstrated the haemolytic and erythropoietic role of the spleen in others with splenomegaly. Blood volume values in healthy individuals were found to be similar to those of normal subjects in other populations. Increased plasma volumes commonly described in non-African patients with anaemia and splenomegaly were also recorded in this group of Sierra Leoneans. Information obtained from these studies indicates that facilities for radioisotope investigations would be an asset in the diagnostic evaluation of complex blood disorders and in haematological research in developing African countries.
The production and radiochemical separation of 52Fe from 4He irradiation of enriched 50Cr target is described. Methods developed for the recovery of the target material (50Cr) are also described. The yield of 52Fe at 38 MeV incident 4He energy is 1667 +/- 133 MBq/C (163 +/- 13 microCi/microAh) at end of bombardment and the contamination of 55Fe is only 0.008%.
A comparison of the rates of clearance of 51Cr labelled and 99mTc labelled heat-damaged red cells in 25 patients and 4 control subjects is reported. Very little correlation was found between the clearance half-times of the two types of labelled cells when the cells were labelled with 99mTc prior to heat damaging. The correlation was improved when the labelling step occurred after the cells had been damaged. Urinary excretion measurements revealed that the rate of excretion of 99mTc could be as much as nine times that of the 51Cr label. 99mTc labelled heat-damaged red cells were found not to be sufficiently stable a preparation for use in quantitative clearance studies.