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Morphine: single-dose tolerance.

C Kornetsky·G Bain
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Abstract

Rats show a significant degree of tolerance to a second dose of morphine, with the degree of tolerance increasing the longer the delay between the two doses of morphine. To measure the morphine effect a foot-shock attenuation procedure that allowed the animal to adjust the shock intensity was used in studying delays of up to 180 days.

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AnimalsDrug ToleranceElectroshockEscape ReactionFootInjections, SubcutaneousMaleMorphineRatsTime FactorsJournal Article

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C Kornetsky, G Bain. 1968-11-29. Morphine: single-dose tolerance.. https://doi.org/10.1126/science.162.3857.1011

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