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Changes in nuclear basic proteins during pseudorabies virus infection.

J G Stevens·G J Kado-Boll·C B Haven
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Abstract

As a preliminary study to investigation of the possible role played by basic proteins in the genetic regulation of virus-infected cells, acid-extractable proteins synthesized during pseudorabies virus infection were investigated. The synthesis of histones was found to decrease in a gradual manner, and arrest was complete by 6 hr after infection. Five virus-induced acid-extractable proteins appeared in nuclei of infected cells after 4 hr of infection. Four of these proteins were virus structural proteins; one was not. All these proteins contained tryptophan and, therefore, were not "classic" histones.

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AnimalsArginineCarbon IsotopesCell LineCulture TechniquesElectrophoresis, DiscHerpesviridaeHistonesKidneyLysineProtein HydrolysatesPseudorabiesRabbitsTritiumTryptophanViral ProteinsJournal Article

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J G Stevens, G J Kado-Boll, C B Haven. 1969. Changes in nuclear basic proteins during pseudorabies virus infection.. https://doi.org/10.1128/jvi.3.5.490-497.1969

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