PubMed · 5799180
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P Siltanen. 1969. [Exercise electrocardiography].. https://pubmed.ncbi.nlm.nih.gov/5799180/
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BACKGROUND: We investigated whether the presence and frequency of asymptomatic ischemic episodes recorded during ambulatory ECG (AECG) monitoring could be predicted on the basis of clinical characteristics or exercise treadmill test (ETT) performance in patients with stable coronary disease and whether the estimate of ischemia severity was similar between the AECG and ETT. METHODS AND RESULTS: Patients screened for the Asymptomatic Cardiac Ischemia Pilot (ACIP) study were selected for the current analysis if data were available from 48-hour AECG monitoring as well as from an ETT during which the patient developed > or = 1-mm ST-segment depression. Exercise ECG data were available for 143 of the 910 patients without ischemic episodes and for 659 of the 910 patients with ischemic episodes during AECG monitoring. Angina was more frequent among patients with ambulatory ischemic episodes than among patients without such ischemia (P < .001). Patients with AECG ischemia had a consistently more marked ischemic response on the ETT than patients without AECG ischemia; patients likely to have AECG ischemia could be predicted on the basis of ETT performance characteristics. However, the correlation coefficients between the severity of ischemia estimated by ETT and by AECG were small. CONCLUSIONS: There are significant relations between ischemia detected by AECG monitoring and by ETT, but the relations are limited, indicating that the two tests are not redundant to characterize coronary patients. A larger study investigating the prognostic significance of the ischemia identified by each modality, with follow-up for clinical events, will be necessary to determine the most appropriate methods to evaluate patients with stable coronary disease.
Cardiovascular disease is the leading cause of death among women, yet clinical trials have not evaluated specific treatment strategies for women. Recently, there has been an expansion of scientific literature exploring differences between women and men with hypertension and cardiovascular disease. The cardioprotective effects of estrogen have been well demonstrated, and the loss of endogenous estrogens with aging contributes to the rapid increase in the incidence of coronary artery disease after menopause. Many of the adverse effects of estrogen deficiency are reversible with estrogen replacement. Estrogen improves lipoprotein profiles, has vasodilatory effects on the endothelium, and inhibits vascular smooth muscle cell growth and constriction. These effects likely all contribute to the reduction in coronary artery disease in the presence of estrogen, and the clinical benefits are not attenuated by concurrent progestins. There are gender-specific differences in the epidemiology of hypertension and coronary artery disease, as well as differences in the pathophysiology and clinical manifestations of disease. Given important experimental interactions between estrogens and the major classes of antihypertensive agents, as well as secondary benefits such as a possible reduction in bone loss with certain agents, a gender-specific approach to hypertension appears to be warranted. Future clinical trials will need to address gender-specific differences in treatment approaches.