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PubMed · 604441

Atypical ocular toxocariasis.

Abstract

The case presented emphasizes that Toxocara Canis can involve the anterior segment of the eye as an isolated disease process. Most cases of ocular Toxocara Canis are not associated with the other features of the visceral larva migrans syndrome but certainly represents a spectrum of the same parasitic disease. At present, an eosinophil count and isohemagglutinin titers against A and B blood groups appear the easiest hematologic studies to perform and are fairly reliable indicators of active Toxocara infestation. The VLM syndrome is usually a benign, self-limited disease but occasionally severe ocular, pulmonary or CNS involvement may result. The diagnosis should be considered in any child with a unilateral ocular inflammatory disease, especially if there is a history of geophagia or exposure to dogs. Treatment must take into account the severity of the disease, the organ involved, and the tendency to produce an inflammatory process upon the death of the organism. Elimination of the disease requires surveillance of dogs, especially puppies, and avoidance of geophagia.

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BibTeXRIS

T J Liesegang. Atypical ocular toxocariasis.. https://pubmed.ncbi.nlm.nih.gov/604441/

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Model of pulsatile-flow of aqueous humor through the iris-lens canal.

PURPOSE: To present a model of pulsatile-flow of aqueous humor from posterior (PC) to anterior chamber (AC) and to analyze the sensitivity of this novel model in detecting typical high risk conditions predisposing to pupillary block. METHODS: The model assumes noncontinuous flow of aqueous through the iris-lens canal. Aqueous that fills the canal will be ejected toward the AC-side of the canal at certain time intervals, and between 2 events of aqueous ejection there is no actual flow through this canal. Pupillary pumping rate (PPR) was calculated from the aqueous flow rate and the calculated volume of iris-lens canal. RESULTS: PPR values were generated by incorporating pupillary diameter (1 to 8 mm), aqueous flow rate (1 to 2.5 microL/min), and iris-lens canal width (0.5 to 2 mm) and height (3-9 microm) in numerical experimentation with the present model. PPR showed inverse dependence on iris-lens canal height and pupillary diameter and was directly proportional to aqueous flow rate, in agreement with the steady-flow model. However, contrary to the steady-flow model, PPR showed inverse dependence on iris-lens canal width and predicted the anticipated PC-AC pressure gradient changes at simulated light-dark transition in eyes of patients with clinically narrow angles and ultrasound biomicroscopy evidenced pupillary block. CONCLUSIONS: Upon the incorporation of real ultrasound biomicroscopy measurements in numerical experimentations with both models, the present pulsatile-flow model, contrary to the steady-flow model, showed good predictability of PC-AC pressure gradient changes in a typical condition predisposing to pupillary block.

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