Amiodarone pulmonary toxicity.

T Colgan; G T Simon; J M Kay; S O Pugsley; J Eydt

doi:10.3109/01913128409018574

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Amiodarone pulmonary toxicity.

T Colgan·G T Simon·J M Kay·S O Pugsley·J Eydt

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Abstract

Numerous cytoplasmic lamellar bodies were seen in many cell types in an open lung biopsy from a patient on amiodarone therapy. These membrane-bound lamellar bodies were characterized by distinct, concentric parallel membranes and peripheral granular densities. Their morphology and distribution suggest a metabolic disorder of phospholipid degradation induced by this drug. The differential diagnosis of lamellar body accumulation in the lung is discussed. This case emphasizes the desirability for ultrastructural study of lung biopsies in such potentially reversible lung disease.

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Amiodarone Arrhythmias, Cardiac Benzofurans Drug Therapy, Combination Heart Ventricles Humans Inclusion Bodies Lung Diseases Macrophages Male Microscopy, Electron Middle Aged Pulmonary Alveoli Case Reports Journal Article Research Support, Non-U.S. Gov't

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T Colgan, G T Simon, J M Kay, S O Pugsley, J Eydt. 1984. Amiodarone pulmonary toxicity.. https://doi.org/10.3109/01913128409018574

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