Multidrug resistance.

V Ling; J Gerlach; N Kartner

doi:10.1007/bf01806390

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PubMed · 6146362

Multidrug resistance.

V Ling·J Gerlach·N Kartner

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Abstract

Mutations resulting in a complex phenotype of cross-resistance and collateral-sensitivity are frequently observed in mammalian cell lines. A cell surface 170 000 dalton glycoprotein (P-glycoprotein) has been identified to be intimately associated with this multidrug resistance phenotype. We speculate that such mutations also occur in advanced cancers and play a major role in contributing to the non-response to combination chemotherapy. In this context, P-glycoprotein may be a useful molecular marker for diagnostic and therapeutic applications.

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ATP Binding Cassette Transporter, Subfamily B, Member 1 Animals Cell Line Cricetinae Cricetulus Drug Resistance Female Genetic Markers Glycoproteins Humans Mutation Ovary Phenotype Journal Article Research Support, Non-U.S. Gov't Review

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V Ling, J Gerlach, N Kartner. 1984. Multidrug resistance.. https://doi.org/10.1007/bf01806390

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