Flushing reactions: consequences and mechanisms.

J K Wilkin

doi:10.7326/0003-4819-95-4-468

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Flushing reactions: consequences and mechanisms.

J K Wilkin

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Abstract

The mechanisms of flushing reactions are pharmacologically and physiologically heterogeneous. Flushing may result from agents acting directly on the vascular smooth muscle or may be mediated by vasomotor nerves. Vasomotor nerves may lead to flushing as a result of events at both peripheral and central sites. In susceptible persons, frequent, intense flushing leads to a cluster of physical signs (rosacea). Flushing provoked by alcohol has been associated with ethnic sensitivity, a possible predisposition to alcoholism, various disulfiramlike agents, one type of diabetes mellitus, and the carcinoid syndrome and other types of neoplasia. Flushing reactions also occur during the menopause, after glutamate ingestion, and in response to oral thermal challenges.

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Chlorpropamide Disulfiram Drug Interactions Endorphins Ethanol Female Glutamates Hot Temperature Humans Malignant Carcinoid Syndrome Menopause Neoplasms Skin Skin Physiological Phenomena Substance P Vasomotor System Journal Article Research Support, Non-U.S. Gov't Review

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J K Wilkin. 1981. Flushing reactions: consequences and mechanisms.. https://doi.org/10.7326/0003-4819-95-4-468

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