[Mouse macrophage interferons].

L M Mentkevich; E V Churbakova

PubMed · 6171097

[Mouse macrophage interferons].

Abstract

Mouse peritoneal macrophages produce two types of interferon: type 1 interferon resistant to pH 2.0 is produced in response to the inoculation of virus and poly(I) . poly(C), type 2 interferon (immune), sensitive to pH 2.0 is induced by phytohemagglutinin and is formed due to phagocytosis of sheep erythrocytes treated with specific antiserum. The virus-induced interferon is produced by macrophages very rapidly (maximum within 1-2 hours), and the antiviral state resulting from it develops within 1-3 hours after inoculation of the inducer. Immunization of mice as well as pretreatment of macrophages with small doses of interferon did not affect their interferon-synthesizing activity. Type 2 interferon produced a marked antiproliferative effect in L cell culture.

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Animals DEAE-Dextran Hydrogen-Ion Concentration Immunization Interferons Macrophages Mice Mice, Inbred C57BL Newcastle disease virus Phagocytosis Phytohemagglutinins Poly I-C Vesicular stomatitis Indiana virus Journal Article

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L M Mentkevich, E V Churbakova. [Mouse macrophage interferons].. https://pubmed.ncbi.nlm.nih.gov/6171097/

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