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Urinary estriol determinations in normal and pathological pregnancies.

K Ryu·S O Chung·Y H Yang·H M Kwak
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EstriolFemaleFetal DeathHumansPre-EclampsiaPregnancyPregnancy ComplicationsUterine HemorrhageJournal Article

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K Ryu, S O Chung, Y H Yang, H M Kwak. 1977. Urinary estriol determinations in normal and pathological pregnancies.. https://doi.org/10.3349/ymj.1977.18.2.123

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OBJECTIVE: The objective was to compare the predictive accuracy (percentage of correct vs incorrect predictions) of salivary estriol levels (SalEst; Biex, Inc, Dublin, Calif) with that of the modified Creasy score for predicting preterm labor followed by preterm delivery. STUDY DESIGN: A triple-blinded prospective trial was conducted at 8 US centers. RESULTS: Among 601 evaluable patients, serial salivary estriol testing correctly predicted the appropriate outcome 91% of the time and the Creasy scoring method correctly predicted the appropriate outcome 75% of the time (McNemar test P <. 001). Among subjects with Creasy scores >/=10 (high-risk group, n = 152), use of salivary estriol testing correctly predicted the end point 87% of the time, compared with only 7.2% correctly predicted by modified Creasy scoring (McNemar test P <.001). CONCLUSION: Salivary estriol assessment was more accurate in predicting outcome than was modified Creasy scoring.

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