Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs.

K C Wright; J H Anderson; C Gianturco; S Wallace; V P Chuang

doi:10.1148/radiology.142.2.6172809

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Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs.

K C Wright·J H Anderson·C Gianturco·S Wallace·V P Chuang

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Abstract

Partial splenic arterial embolization (50% reduction in flow) was evaluated in dogs using polyvinyl alcohol foam or microspheres (20-500 mu) made of dextran, polystyrene, or silicone. Dextran and polystyrene were found to be superior for several reasons: they were easier to use, did not shatter when agitated, and produced permanent, homogeneous, peripheral occlusion with only one administration. Partial embolization with dextran or polystyrene increased platelet levels within 1 week and markedly reduced splenic size with minimal if any collateral filling within 6 weeks. Microscopically, no acute infarction or necrosis was seen at 6 weeks; there was some fibrosis, but the remaining parenchyma appeared normal.

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Animals Anion Exchange Resins Dextrans Dogs Embolization, Therapeutic Gels Hypersplenism Ion Exchange Resins Microspheres Platelet Count Polyvinyls Resins, Synthetic Silicones Splenic Artery Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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K C Wright, J H Anderson, C Gianturco, S Wallace, V P Chuang. 1982. Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs.. https://doi.org/10.1148/radiology.142.2.6172809

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