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PubMed · 62001

Characterization of antibodies to the structural polypeptides of HGSAg: evidence for subtype-specific determinants.

J W Gold·J W Shih·R H Purcell·J L Gerin
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Abstract

Antisera prepared in guinea pigs to the structural polypeptides of HBAAg/adw and HBSAg/ayw were examined by a modified passive hemagglutination assay for antibodies to the subtype-specific d and y determinants. All of the isolated polypeptide fractions stimulated antibodies to both group specific and subtype-specific antigens of the native HBSAg particle from which they were derived. These data indicate that the polypeptides have similarities in their immunochemical structure.

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AnimalsAntibodies, ViralCarrier StateEpitopesGuinea PigsHepatitis B Surface AntigensHepatitis, Viral, HumanHumansPeptidesJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J W Gold, J W Shih, R H Purcell, J L Gerin. 1976. Characterization of antibodies to the structural polypeptides of HGSAg: evidence for subtype-specific determinants.. https://pubmed.ncbi.nlm.nih.gov/62001/

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