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Lyb3: a B cell surface antigen associated with triggering secretory differentiation.

J D Kemp·J W Rohrer·B T Huber
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Abstract

The results discussed in this review show that the TNP-specific IgA lambda 2-secreting BALB/c plasmacytoma MOPC-315 is partially composed of small lymphocytoid, presecretory cells which express the Lyb3 determinant. It is shown that MOPC-315 cell secretory differentiation, but not clonal proliferation, can be modulated by anti-Lyb3. Anti-Lyb3 serum has been shown to: 1) augment secretory differentiation enhancement by suboptimal numbers of secretory differentiation-enhancing, IgA315-specific helper T cells; 2) replace this secretory differentiation-enhancing T cell population as long as clone growth helper T cells are present; and 3) block suppression of secretory differentiation mediated by carrier-immune Ts cells. These results demonstrate that whether anti-Lyb3 serum enhances immune responses by replacing or augmenting a helper signal or by counteracting suppressor signals, the effects are focused on secretory differentiation events and have no effect on clonal proliferation.

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Antibodies, MonoclonalAntigens, LyB-LymphocytesCell DifferentiationImmunoglobulinsLymphocyte CooperationT-Lymphocytes, Helper-InducerJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J D Kemp, J W Rohrer, B T Huber. 1982. Lyb3: a B cell surface antigen associated with triggering secretory differentiation.. https://doi.org/10.1111/j.1600-065x.1983.tb00452.x

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