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PubMed · 622549

[D-xylose absorption test. A pharmacokinetic and statistical study].

P Huguenin·B Cochet·L Balant·E Loizeau
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Abstract

D-xylose pharmacokinetics has been studied in 6 healthy subjects by serial measurement of blood and urinary levels following oral and intravenous administration of two doses of D-xylose (5 and 25 g successively). Furthermore, patients with obesity, renal or hepatic insufficiency, or with a T-drain after cholecystectomy, are also investigated. Both the rate and completeness of D-xylose absorption and the apparent distribution volume of D-xylose present noteworthy interindividual variations, so that the time and value of the peak blood level are highly variable as between healthy subjects. Renal insufficiency increases the apparent elimination half-life of D-xylose and notably reduces D-xylose renal excretion. This study provides pharmacokinetic evidence of the very wide range of blood and urinary levels observed in the D-xylose tolerance test, and emphasizes the fact that D-xylose urinary excretion alone is not a reliable index of intestinal absorption.

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Administration, OralAdultFemaleHumansInfusions, ParenteralIntestinal AbsorptionKidney Failure, ChronicLiver DiseasesMaleObesityPleural EffusionXyloseEnglish AbstractJournal Article

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P Huguenin, B Cochet, L Balant, E Loizeau. 1978-02-11. [D-xylose absorption test. A pharmacokinetic and statistical study].. https://pubmed.ncbi.nlm.nih.gov/622549/

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