Cannabinoids and the cholinergic system.

E F Domino

doi:10.1002/j.1552-4604.1981.tb02602.x

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Cannabinoids and the cholinergic system.

E F Domino

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Abstract

delta 9-Tetrahydrocannabinol (THC) decreases EEG activation and causes slow waves in the cat. The EEG slow-wave activity is accompanied by a concomitant decrease in acetylcholine release from the neocortex. The findings suggest that THC depresses the brain stem activating system. Large doses of delta 8- and delta 9-THC increase brain acetylcholine levels in rodents such as the mouse and rat, but this effect is not seen with minimal doses of the cannabinoids which show behavioral effects. The most dramatic change produced by THC is that brain acetylcholine utilization is reduced primarily in the hippocampus.

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Acetylcholine Animals Brain Cannabinoids Cats Cerebral Cortex Dronabinol Electroencephalography Mice Parasympathetic Nervous System Rats Journal Article

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E F Domino. Cannabinoids and the cholinergic system.. https://doi.org/10.1002/j.1552-4604.1981.tb02602.x

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