Birth defects and vaginal spermicides.

S Shapiro; D Slone; O P Heinonen; D W Kaufman; L Rosenberg; A A Mitchell; S P Helmrich

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PubMed · 6279895

Birth defects and vaginal spermicides.

S Shapiro·D Slone·O P Heinonen·D W Kaufman·L Rosenberg·A A Mitchell·S P Helmrich

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Abstract

In a cohort study of 50, 282 pregnancies recruited between 1958 and 1965, there were 462 gravidae who used nonmercurial spermicides (mostly nonoxynol-9 (95% confidence limits, 0.6 to 1.6). There were also 889 women who used phenylmercuric acetate (no longer available as a spermicide); the corresponding rate ratio was 0.9 (0.6 to 1.3). Limb reduction deformities, neoplasms, Down's syndrome, and hypospadias did not occur in excess in children exposed to spermicides.

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Abnormalities, Drug-Induced Abortion, Spontaneous Female Humans Infant, Newborn Nonoxynol Octoxynol Phenylmercuric Acetate Polyethylene Glycols Pregnancy Prospective Studies Spermatocidal Agents Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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S Shapiro, D Slone, O P Heinonen, D W Kaufman, L Rosenberg, A A Mitchell, S P Helmrich. 1982-05-07. Birth defects and vaginal spermicides.. https://pubmed.ncbi.nlm.nih.gov/6279895/

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