PubMed · 6282887
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
J W Ogilvie. 1982. Malignant eccrine acrospiroma. A case report.. https://pubmed.ncbi.nlm.nih.gov/6282887/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Ceruminomata are tumours spreading from the ceruminous glands of the external auditory canal. Since 1894 190 cases have been described, but nomenclature is still confusing to some extent. Syringocystadenoma papilliferum is a special subgroup. 189 cases are reported in the literature; 11 tumours have been observed in the auditory canal. A further case is reported in this paper.
Malignant spiradenomas (spiradenocarcinomas) are exceedingly rare tumours of cutaneous adnexal origin, consisting of two components: benign--the pre-existent adenoma, and malignant--developing from the former part. We studied p53 protein expression in both compartments of three cases of malignant spiradenoma and compared these results with results obtained with eight cases of spiradenoma. Nuclear staining was consistently negative in all benign tumours, whilst in the cases of malignant transformation within spiradenoma p53 protein was present in the carcinomatous component, but the immunostaining remained negative in the benign counterpart of the tumour. In the zone of transition between both components of the spiradenocarcinomas p53 expression was positive in the cells with morphological atypia, providing clear discrimination. Thus, we conclude that the accumulation of p53 protein, which results from alterations in its turnover, accompanies the process of malignant transformation within long-standing spiradenomas.
BACKGROUND: Review of the literature reveals that malignant spiradenomas are rare and may be fatal, and typically manifest as rapid enlargement in long-standing spiradenomas. OBJECTIVE: The present tumor was removed 2 months after it was first noted by the patient. A case of what we believe is the earliest stage of malignant transformation within spiradenoma is reported. METHODS: Case report and literature review. RESULTS: The region with malignant transformation was characterized by nuclear pleomorphism, loss of two cell types, and increased mitotic activity with atypical mitoses. Small infiltrating duct-like structures were seen. The large aggregates and sheets of malignant cells described in long-standing tumors were not seen. CONCLUSION: We ascribe the early detection of this tumor to increased public awareness of the importance in seeking early treatment of skin lesions. Histologic examination of this stage may eventually outnumber the now more commonly described latter stages.