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PubMed · 6360166

[Demonstration of circulating immune complexes using a C1q-solid phase enzyme immunoassay].

W Schössler·F Hiepe·K Courault·B Porstmann·E Apostoloff
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Abstract

An enzyme-immunoassay for the quantitative determination of circulating immune complexes in human serum is described. The technique uses alkaline phosphatase-conjugated anti-human IgG to detect immune complexes bound to solid phase C1q. This assay is sensitive detecting 4 ng/ml to 60 micrograms/ml aggregated IgG. First data from normal individuals and patients with systemic lupus erythematosus show that this method is specific and sensitive for detection of circulating immune complexes.

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Antigen-Antibody ComplexComplement Activating EnzymesComplement C1qHumansImmunoenzyme TechniquesImmunoglobulin GLupus Erythematosus, SystemicEnglish AbstractJournal Article

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W Schössler, F Hiepe, K Courault, B Porstmann, E Apostoloff. 1983. [Demonstration of circulating immune complexes using a C1q-solid phase enzyme immunoassay].. https://pubmed.ncbi.nlm.nih.gov/6360166/

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