Influence of naloxone on the captopril-induced decrease in vagal pressor reflexes.

P Montastruc; J L Montastruc; G Gaillard-Plaza

PubMed · 6396447

Influence of naloxone on the captopril-induced decrease in vagal pressor reflexes.

P Montastruc·J L Montastruc·G Gaillard-Plaza

Abstract

The effects of intracisternal injection of captopril (0.3 mg/kg) on the pressor responses elicited by afferent stimulation of the vagus were investigated in the anaesthetized dog. The captopril-induced decrease in the systolo-diastolic pressor response to vagal stimulation was reversed by subsequent injection of naloxone (0.1 mg/kg, i.v.). These results suggest the involvement of central opioid mechanisms in the hypotensive properties of captopril.

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Animals Blood Pressure Captopril Dogs Electric Stimulation Female Male Naloxone Proline Vagus Nerve Journal Article Research Support, Non-U.S. Gov't

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P Montastruc, J L Montastruc, G Gaillard-Plaza. Influence of naloxone on the captopril-induced decrease in vagal pressor reflexes.. https://pubmed.ncbi.nlm.nih.gov/6396447/

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