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PubMed · 6412342

[Is valproic acid teratogenic?].

E Robert·J M Robert·C Lapras
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Abstract

In more than 7 000 cases of neonatal malformations processed up to 1982 in a regional computer register 71 infants had been born from epileptic mothers. A significantly higher than expected number of spina bifida aperta were observed in this group, related to the administration to the mother of the anti-epileptic agent valproic acid. A pathogenic hypothesis and a possible preventive procedure for this type of malformation are discussed.

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Abnormalities, Drug-InducedAdultDose-Response Relationship, DrugEpilepsyFemaleHumansInfantInfant, NewbornMeningomyelocelePregnancyPregnancy ComplicationsRiskValproic AcidEnglish AbstractJournal Article

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E Robert, J M Robert, C Lapras. 1983. [Is valproic acid teratogenic?].. https://pubmed.ncbi.nlm.nih.gov/6412342/

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