PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 641805

Mathematical basis of point-area deconvolution method for determining in vivo input functions.

D P Vaughan·M Dennis
View original source ↗Export metadata ↓

Abstract

The point-area method for deconvolution derives a "staircase" input function which, when convolved onto the characteristic function, gives an output function coincidental with the given output data points. The area--area method for deconvolution is shown to be erroneous.

Explore related subjects

MathematicsModels, BiologicalPharmaceutical PreparationsSolubilityJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

D P Vaughan, M Dennis. 1978. Mathematical basis of point-area deconvolution method for determining in vivo input functions.. https://doi.org/10.1002/jps.2600670524

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1979

Dielectric noise in membranes.

Most theoretical and experimental studies of electrical fluctuations in membranes so far have been devoted to noise associated with conduction processes. In this paper a different type of noise is described which results from dipolar transitions in the membrane. Two mechanisms for the generation of such dielectric noise are analyzed: (a) conformational transitions of membrane proteins involving changes in dipolar moment and/or polarizibility, and (b) rotation of dipolar molecules dissolved in the lipid. The spectral intensity of current noise calculated for the two models exhibits a characteristic dependence on frequency omega with a decrease proportional to omega 2 towards low frequencies and an approach to a frequency-independent (white noise) limit at high frequencies. For a given number of dipolar molecules in the membrane, the spectral intensity is inversely proportional to the square of the membrane thickness.

Mathematics↗