Enteric-coated aspirin, platelet cyclooxygenase activity and function.

G H Rao; E Radh; G J Johnson; J G White

doi:10.1016/0262-1746(84)90049-0

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Enteric-coated aspirin, platelet cyclooxygenase activity and function.

G H Rao·E Radh·G J Johnson·J G White

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Abstract

Recent studies evaluating the effect of slow releasing enteric-coated aspirin formulations have reported contradictory findings regarding the bioavailability of the active molecule in the circulating blood and the length of duration of the inhibitory effect on platelet function. In the present study, we have evaluated the effect of a single dose of two commercially available enteric-coated aspirins on platelet arachidonic acid metabolism and function. A single dose of slow releasing aspirin was as effective as fast acting regular aspirin in its effect on cyclooxygenase activity and platelet function in both human and canine platelets. However, in view of its slow releasing property, the onset of inhibition was considerably delayed compared to the action of fast acting aspirin in those subjects who ingested enteric-coated aspirins.

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Animals Arachidonic Acids Aspirin Biological Availability Blood Platelets Cyclooxygenase Inhibitors Dogs Humans Prostaglandin-Endoperoxide Synthases Tablets, Enteric-Coated Thromboxane B2 Time Factors Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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G H Rao, E Radh, G J Johnson, J G White. 1984. Enteric-coated aspirin, platelet cyclooxygenase activity and function.. https://doi.org/10.1016/0262-1746(84)90049-0

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