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PubMed · 6428433

Immunomodulation by Bacillus subtilis spores.

G Benedettini·G De Libero·R Pierotti·M Campa·G Falcone
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Abstract

This study was undertaken in order to investigate the immunomodulatory effect of heat-killed Bacillus subtilis spores as well as of one soluble and one insoluble fraction obtained after their mechanical breakage. The results demonstrate that heat-killed spores, the soluble and the insoluble fraction enhance the primary PFC response to T-dependent antigens such as SRBC and HRBC, but not to T-independent antigens such as Ficoll-TNP. However, the same doses capable of enhancing the production of antibodies against T-dependent antigens were unable to modify the host CMI, evaluated in terms of contact sensitivity to oxazolone.

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AnimalsAntibody FormationAntigens, T-IndependentBacillus subtilisErythrocytesFicollHorsesImmunity, CellularMiceSheepSpores, BacterialTrinitrobenzenesJournal Article

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G Benedettini, G De Libero, R Pierotti, M Campa, G Falcone. 1983. Immunomodulation by Bacillus subtilis spores.. https://pubmed.ncbi.nlm.nih.gov/6428433/

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