PubMed · 6457573
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D D Nghiem. 1981. Dacron Velour prosthesis.. https://pubmed.ncbi.nlm.nih.gov/6457573/
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Microspheres of ovalbumin (OVA) ranging from 1 to 15 microm were prepared by emulsifying an aqueous solution of albumin in soya oil at room temperature then raising the temperature to 45 degrees C for 30 min, prior to harvesting of the microspheres. Production of OVA nanospheres with size less than 500 nm was achieved by desolvation from aqueous albumin solutions using acetone. In both cases, lactic acid was added to the starting albumin solution to stabilise the resulting particles. Utilisation of an endogenous substance avoids the use of chemical crosslinking agents such as glutaraldehyde and associated toxicological concerns. Protein coating of knitted Dacron vascular grafts was performed by impregnation of the textile structure with lactic acid-stabilised ovalbumin nanospheres thereby providing a surface potentially resistant to blood platelet adhesion but conducive to endothelialisation. Protein release testing carried out in PBS at 37 degrees C revealed that approximately 60% of the original albumin coating was retained by the Dacron graft material after 4 days and remained at this level for upto 4 weeks. Apart from the formulation of albumin microspheres for drug delivery, diagnostic applications and coating of biomedical textiles, the process of albumin stabilisation using lactic acid may be usefully applied to improve protein immobilisation on a wide range of biomaterial surfaces.
Serial intracoronary ultrasound studies revealed significant postprocedural stent expansion accompanied by significant stent shortening during long-term follow-up. The disadvantageous lumen loss by neointimal formation could be balanced by late stent expansion.
BACKGROUND: Some surgeons who use carotid patching favour using the saphenous vein, whilst others favour synthetic materials. OBJECTIVES: The objective of this review was to assess the effect of different materials for carotid patch angioplasty. SEARCH STRATEGY: We searched the Cochrane Stroke Group trials register, Medline (1966 to 1995), Embase (1980 to 1995) and Index to scientific and technical proceedings (1980 to 1994). We handsearched Annals of Surgery (1981 to 1995), British Journal of Surgery (1985 to 1995), European Journal of Vascular and Endovascular Surgery (1987 to 1995) and World Journal of Surgery (1978 to 1995). SELECTION CRITERIA: Randomised trials comparing one type of carotid patch with another for carotid endarterectomy. DATA COLLECTION AND ANALYSIS: One reviewer applied the inclusion criteria and extracted the data. Trial quality was assessed. MAIN RESULTS: Three trials involving 326 operations were included. The trials compared saphenous vein patches with synthetic polytetrafluroethylene patches. Allocation was not adequately concealed in two trials, and only one followed-up patients until hospital discharge. Intention-to-treat analysis was only possible for the latter trial. In all trials a patient could be randomised twice and have each carotid artery randomised to different treatment groups. One trial was excluded from the analyses of death and any stroke because it was not possible to clarify how many patients, rather than arteries, were allocated to each treatment. There were too few events to determine whether there was any difference between the patch materials for perioperative stroke, death and arterial complications. During longterm follow-up for more than one year, no difference was shown between the two types of patch for the risk of stroke, death, or arterial restenosis. However, the number of events was small. Based on 236 patients in two trials, there were significantly fewer pseudoaneurysms associated with synthetic patches (odds ratio 0.15, 95% confidence interval 0.05 to 0.44). REVIEWER'S CONCLUSIONS: There is not enough evidence to differentiate between venous and synthetic patches in carotid endarterectomy.