Synaptic density in chronic animals with experimental neurofibrillary changes.

E Uemura; W P Ireland

doi:10.1016/0014-4886(84)90154-7

Home/Archive/PubMed

PubMed · 6539712

Synaptic density in chronic animals with experimental neurofibrillary changes.

E Uemura·W P Ireland

View original source ↗Export metadata ↓

Abstract

Synaptic density was quantitated in the cerebral cortex and subiculum of rabbits with experimental neurofibrillary changes. Animals were subjected to subcutaneous injection of aluminum tartrate for 90 days, and synapses stained with ethanolic phosphotungstic acid were analyzed in animals killed 100, 200, or 300 days postinjection with aluminum tartrate. A significant difference was found in synaptic density between animals injected with aluminum tartrate and their age-matched controls. This difference was a result of a low synaptic density present in animals killed 200 or 300 days postinjection of aluminum tartrate. In contrast, animals killed 100 days postinjection revealed the same synaptic density as their control. The data suggest that the synaptic depopulation associated with experimental neurofibrillary changes is a gradual process, and such changes are demonstrable only long after the initial appearance of neurofibrillary changes.

Explore related subjects

Aluminum Alzheimer Disease Animals Brain Brain Diseases Cerebral Cortex Disease Models, Animal Humans Microscopy, Electron Neurofibrils Rabbits Synapses Tartrates Journal Article Research Support, U.S. Gov't, P.H.S.

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

E Uemura, W P Ireland. 1984. Synaptic density in chronic animals with experimental neurofibrillary changes.. https://doi.org/10.1016/0014-4886(84)90154-7

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Direct demonstration of enhanced diffusion in mesoporous ZSM-5 zeolite obtained via controlled desilication.

A 2 orders of magnitude gas transport improvement in a medium pore ZSM-5 zeolite has been achieved upon introduction of intracrystalline mesoporosity in gradient-free crystals by desilication post-treatment in alkaline medium.

Aluminum↗

PubMed2007

Estimates of ambient background concentrations of trace metals in soils for risk assessment.

Site-specific or soil type-specific ambient background concentrations (ABCs) of trace metals in soils are needed for risk assessment. We investigated three different methods for estimating ABCs in soils using a dataset of 5691 soil samples from England and Wales. The concentrations of Co, Cr and Ni were strongly associated with Al and Fe, and multiple regressions explained 62-85% of their variation, and Al and Fe can therefore be used to predict ABCs for these metals. Soil texture had a major influence on the concentrations of Cd, Co, Cr, Cu, Ni and Zn, and the medians were 3-5 fold higher in clayey than in sandy soils. This was used to predict texture-specific ABCs. Lead concentration was higher in acidic peaty soils than in other soils. A probability graph method was used to estimate ABC for Pb in a population of relatively uncontaminated soils. Potential applications of ABCs are discussed.

Aluminum↗

PubMed2007

Quantitative trait loci and candidate gene mapping of aluminum tolerance in diploid alfalfa.

Aluminum (Al) toxicity in acid soils is a major limitation to the production of alfalfa (Medicago sativa subsp. sativa L.) in the USA. Developing Al-tolerant alfalfa cultivars is one approach to overcome this constraint. Accessions of wild diploid alfalfa (M. sativa subsp. coerulea) have been found to be a source of useful genes for Al tolerance. Previously, two genomic regions associated with Al tolerance were identified in this diploid species using restriction fragment length polymorphism (RFLP) markers and single marker analysis. This study was conducted to identify additional Al-tolerance quantitative trait loci (QTLs); to identify simple sequence repeat (SSR) markers that flank the previously identified QTLs; to map candidate genes associated with Al tolerance from other plant species; and to test for co-localization with mapped QTLs. A genetic linkage map was constructed using EST-SSR markers in a population of 130 BC(1)F(1) plants derived from the cross between Al-sensitive and Al-tolerant genotypes. Three putative QTLs on linkage groups LG I, LG II and LG III, explaining 38, 16 and 27% of the phenotypic variation, respectively, were identified. Six candidate gene markers designed from Medicago truncatula ESTs that showed homology to known Al-tolerance genes identified in other plant species were placed on the QTL map. A marker designed from a candidate gene involved in malic acid release mapped near a marginally significant QTL (LOD 2.83) on LG I. The SSR markers flanking these QTLs will be useful for transferring them to cultivated alfalfa via marker-assisted selection and for pyramiding Al tolerance QTLs.

Aluminum↗