Age differences in cisplatinum nephrotoxicity.

D Appenroth; H Bräunlich

doi:10.1016/0300-483x(84)90086-6

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PubMed · 6541377

Age differences in cisplatinum nephrotoxicity.

D Appenroth·H Bräunlich

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Abstract

Male and female Wistar rats (5-105-day-old) were administered 3 different doses of cisplatinum (CP) (0.15, 0.3 or 0.6 mg/100 g body wt, intraperitoneally) After 3 days the renal excretory functions were investigated. There were no sex differences in nephrotoxicity. In rats of all age groups a dose dependent decrease in body weight appeared. In 5- and 33-105-day-old rats the 2 lower doses did not or only mildly influence renal function. 0.6 mg CP/100 g body wt in these age groups lead to a significant reduction in urine volume. The excretion of osmotically active substances and p-aminohippurate were reduced. There is a statistically significant proteinuria. In 10- and 15-day-old rats the 2 lower doses were without any pathologic consequences, but 0.6 mg CP/100 g body wt was followed by a significant increase in the protein excretion of 15-day-old rats. Consequently, regarding the parameters measured 10-15-day-old rats seemed to be less susceptible to CP-nephrotoxicity.

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Aging Animals Body Weight Cisplatin Female Injections, Intraperitoneal Kidney Lethal Dose 50 Male Rats Rats, Inbred Strains Sex Factors p-Aminohippuric Acid Journal Article

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D Appenroth, H Bräunlich. 1984-09-28. Age differences in cisplatinum nephrotoxicity.. https://doi.org/10.1016/0300-483x(84)90086-6

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