PubMed · 65641
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P D Clarke, A M Geddes. 1977-03-05. Drugs for typhoid fever.. https://doi.org/10.1016/s0140-6736(77)91407-6
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66 patients from a nephrological out-patient clinic in whom an ampicillin-sensitive pathogen had been demonstrated after suprapubic puncture, were divided into 3 randomised groups. The first group received 10, the second 20 and the third 30 tablets of 800 mg bacampicillin each. Tablets were given t.i.d. Due to randomising comparable groups were formed. When different criteria were used for assessment of success no advantages of long-term or disadvantages of short-term treatment were found. 10 tablets (possibly even less) are thus the minimal inhibitory dosage for the disease. Present experience suggests a short treatment with follow-up controls at short intervals and then a long-term reinfection prophylaxis.