PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6595082

Clinical experience with the Robin sequence.

H M Pasyayan·M B Lewis
View original source ↗Export metadata ↓

Abstract

In 1980 the results of a trial program of intense non-surgical management on ten consecutive newborn infants admitted with the Robin sequence were reported. The diagnosis of Robin sequence was made based upon the presence of retrognathia and glossoptosis in a newborn infant with or without cleft palate. Upper airway obstruction and feeding difficulties were also present in the post natal and neonatal period. An additional 15 patients were managed using the same protocol. These 25 consecutive patients are divided into two distinct groups. Seventeen have the isolated Robin sequence (IRS) and eight have the Robin sequence as part of a syndrome or associated with multiple congenital anomalies (RSS). A definite trend showing normal growth and development in the isolated Robin sequence is noted.

Explore related subjects

Airway ObstructionBody HeightBody WeightBottle FeedingChild, PreschoolCleft PalateFemaleFollow-Up StudiesHeadHumansInfantInfant CareInfant, NewbornIntellectual DisabilityMalePierre Robin SyndromeSpeechJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H M Pasyayan, M B Lewis. 1984. Clinical experience with the Robin sequence.. https://pubmed.ncbi.nlm.nih.gov/6595082/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1996

Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.

Interleukin-11 is a pleotropic cytokine produced by lung stromal cells in response to respiratory viruses, cytokines, and histamine. To further define its potential effector functions, the Clara cell 10-kD protein promoter was used to express IL-11 and the airways of the resulting transgene mice were characterized. In contrast to transgene (-) littermates, the airways of IL-11 transgene (+) animals manifest nodular peribronchiolar mononuclear cell infiltrates and impressive airways remodeling with subepithelial fibrosis. The inflammatory foci contained large numbers of B220(+) and MHC Class II(+) cells and lesser numbers of CD3(+), CD4(+), and CD8(+) cells. The fibrotic response contained increased amounts of types III and I collagen, increased numbers of alpha smooth muscle actin and desmin-containing cells and a spectrum of stromal elements including fibroblasts, myofibroblasts, and smooth muscle cells. Physiologic evaluation also demonstrated that 2-mo-old transgene (+) mice had increased airways resistance and non-specific airways hyperresponsiveness to methacholine when compared with their transgene (-) littermates. These studies demonstrate that the targeted expression of IL-11 in the mouse airway causes a B and T cell-predominant inflammatory response, airway remodeling with increased types III and I collagen, the local accumulation of fibroblasts, myofibroblasts, and myocytes, and obstructive physiologic dysregulation. IL-11 may play an important role in the inflammatory and fibrotic responses in viral and/or nonviral human airway disorders.

Airway Obstruction↗
PubMed1996

[Peak-flow monitoring in asthmatic patients: indications and therapeutic implications of the measurements with reference to the 'traffic-light system'].

Peak flow meters do not allow to perform lung function analysis in the private practice. However, they can be used for the diagnosis of reversible airway obstruction, to search for exacerbation factors in asthma, and to monitor drug therapy in chronic asthma. Peak flow measurements provide the means for self-assessment and self-management of asthma by the patients themselves allowing treatment to be optimized and guaranteeing a better quality of life. The plotting of daily pre- and post-bronchodilator peak flow values enables the patient to understand the pathophysiologic changes in his respiratory tract. Therapeutic implications are easily recognized and can be performed without delay by the patient himself on the basis of the so-called "traffic light system".

Airway Obstruction↗