Surface antigen changes during B-lymphocyte activation in primates.

N L Letvin; W R Aldrich; D A Thorley-Lawson; S F Schlossman; L M Nadler

doi:10.1016/0008-8749(84)90087-x

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Surface antigen changes during B-lymphocyte activation in primates.

N L Letvin·W R Aldrich·D A Thorley-Lawson·S F Schlossman·L M Nadler

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Abstract

It is shown that B-cell-specific surface antigens are conserved on lymphocytes from phylogenetically distant primate species. Characterization of the expression of those antigens on the surface of simian B lymphocytes has led to two observations with important implications for human B-cell physiology. First, lectin stimulation in vitro or antigen stimulation in situ in lymph nodes drives a population of human B lymphocytes to express the B2 but not the B1 antigen on its surface. Second, under pathologic circumstances, this activated B cell can be found in the peripheral blood of monkeys. Thus, the "B2 only" cell defines an activated B lymphocyte whose presence may provide useful diagnostic information concerning pathologic processes.

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Animals Antigens, Surface Aotus trivirgatus B-Lymphocytes Cercopithecidae Galago Humans Hylobates Lemur Lymph Nodes Lymphocyte Activation Macaca mulatta Pan troglodytes Phylogeny Pokeweed Mitogens Saguinus Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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N L Letvin, W R Aldrich, D A Thorley-Lawson, S F Schlossman, L M Nadler. 1984. Surface antigen changes during B-lymphocyte activation in primates.. https://doi.org/10.1016/0008-8749(84)90087-x

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