A diffusible molecule may mediate glutamate neurotoxicity.

C H Zambrano; A G Hyndman

doi:10.1016/0165-3806(83)90038-x

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PubMed · 6627031

A diffusible molecule may mediate glutamate neurotoxicity.

C H Zambrano·A G Hyndman

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Abstract

Purified neuronal cultures from 8-day chick embryo neural retinas were incubated in either serum-free N1 or N1 supplemented with heart extract. The addition of glutamate decreased neuronal survival only in the presence of heart extract; however, if heart extract was dialyzed, neuronal survival remained at control values. This suggests a diffusible molecule may mediate glutamate neurotoxicity Kainic acid decreased neuronal survival in all conditions tested.

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Animals Biomechanical Phenomena Cell Survival Cells, Cultured Chick Embryo Glutamates Kainic Acid Neurons Retina Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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C H Zambrano, A G Hyndman. 1983. A diffusible molecule may mediate glutamate neurotoxicity.. https://doi.org/10.1016/0165-3806(83)90038-x

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