PubMed HealthSearch

PubMed · 6645866

Spline solution to terminal zero acceleration problems in biomechanical data.

Abstract

An augmented cubic spline function was evaluated as an alternative solution to the end-point problem which frequently arises in the smoothing and differentiation of biomechanical position-time data. The usual procedures of natural cubic spline functions and digital filtering have the undesirable effect of forcing the accelerations to zero at the ends of the data set. The proposed augmented cubic spline procedure does not have this characteristic but rather requires the curve to pass through a single extra point at each end of the data set. Using two different criteria with large acceleration magnitudes near the end of the data set, we have compared the effectiveness of all three methods in terms of the total curve (root mean square error) and in terms of the last few points (percent and algebraic error). In both experiments the augumented cubic spline procedure was found to be superior to both digital filtering and natural cubic spline functions. It was concluded that this technique could be used for smoothing and differentiating biomechanical data in instances where the underlying function is unknown and the accelerations at the end points of the data set are suspected of being non-zero.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

S J Phillips, E M Roberts. 1983. Spline solution to terminal zero acceleration problems in biomechanical data.. https://pubmed.ncbi.nlm.nih.gov/6645866/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets.

We have studied the mechanism of interaction between soluble von Willebrand factor (vWF), labeled with fluorescein isothiocyanate (FITC), and platelets exposed to shear in a cone-and-plate viscometer. A flow cytometer calibrated with fluorescent bead standards was used to calculate the number of molecules associated with each platelet in suspension. To validate the methods and reagents used, binding of the same labeled vWF was assessed in the presence of ristocetin or alpha-thrombin and found to be saturable, with a narrow and symmetric distribution on > 90% of the platelets. As expected, essentially all bound ligand interacted exclusively with platelet membrane glycoprotein (GP) Ib alpha in the presence of ristocetin and with GP IIb-IIIa after stimulation with alpha-thrombin. In contrast, only a minor proportion (< 20%) of the platelets exposed to shear were found to bind vWF, with no evidence for saturation and markedly decreased interaction when the platelet count was below 100,000 microliters. Moreover, shear-induced vWF binding was blocked equally effectively by selected monoclonal antibodies against either GP Ib alpha or GP IIb-IIIa or against the respective binding sites in vWF. Thus, both receptors are involved in the process, possibly through initial transient interactions mediated by GP Ib alpha that lead to platelet activation and subsequent irreversible binding supported by GP IIb-IIIa. While the levels of shear stress theoretically applied to platelets in these experiments are above those thought to occur in the normal circulation, our findings demonstrate a unique vWF binding mechanism that is not mimicked by other known modulators and correlates with platelet aggregation. Similar processes may occur in response to lower shear stress when platelets are exposed to thrombogenic surfaces and agonists generated at sites of vascular injury during thrombus formation.

Biomechanical Phenomena