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Cows' milk-sensitive enteropathy.

J Walker-Smith·M Harrison·A Kilby·A Phillips·N France
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Abstract

Serial small intestinal biopsies related to withdrawal and challenge with cows' milk are described in 5 infants with cows' milk protein intolerenace. On the basis of these serial observations the existence of a cows' milk-sensitive enteropathy in infancy is clearly established. The cows' milk-sensitive mucosal lesion varied in its severity ranging from a partly flat mucosa to a mild degree of partial villous atrophy. Intraepithelial lymphocyte counts rose after a positive milk challenge, but on only one occasion to a level outside the normal range. The technique of serial biopsies related to dietary milk enables a firm diagnosis of cows' milk intolerance to be made upon the basis of a single milk challenge. Clinically this appears to be a temporary condition which disappears by the age of 2 years.

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AnimalsBiopsyCattleDiarrhea, InfantileDisaccharidasesFemaleHumansInfantInfant, NewbornIntestinal MucosaLeukocyte CountLymphocytesMalabsorption SyndromesMaleMilk ProteinsJournal Article

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J Walker-Smith, M Harrison, A Kilby, A Phillips, N France. 1978. Cows' milk-sensitive enteropathy.. https://doi.org/10.1136/adc.53.5.375

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