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PubMed · 6684459

CDP-choline: acute toxicity study.

T Grau·A Romero·A Sacristán·J A Ortiz
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Abstract

The acute toxicity of a single dose of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) by different administration routes in mice and rats has been studied. LD50 values were determined according to the cumulative method by Reed-Muench for mortality rate, and Pizzi's method for calculation of standard error.

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Administration, OralAnimalsCholineCytidine Diphosphate CholineFemaleInjections, IntravenousLethal Dose 50MaleMiceRatsRats, Inbred StrainsSpecies SpecificityJournal Article

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BibTeXRIS

T Grau, A Romero, A Sacristán, J A Ortiz. 1983. CDP-choline: acute toxicity study.. https://pubmed.ncbi.nlm.nih.gov/6684459/

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A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence.

PURPOSE: We evaluated the efficacy and safety of yohimbine and isoxsuprine or pentoxifylline in the management of vasculogenic erectile dysfunction. MATERIALS AND METHODS: A total of 20 patients diagnosed with arterial insufficiency and cavernous venous leakage by pharmacological penile duplex scanning underwent nonhormonal oral therapy. A randomized crossover study was performed using 5.4 mg. yohimbine plus 10 mg. isoxsuprine or 400 mg. pentoxifylline 3 times daily. Response to therapy was assessed by a sexual questionnaire and repeat penile duplex ultrasonography. RESULTS: No patient in either phase of the study in either group had a complete response to the oral regimen(s) and there was no improvement in the pre-injection or post-injection cavernous arterial peak systolic flow velocities or resistance indexes. CONCLUSIONS: Our study suggests that these oral agents, although well tolerated, were not effective in the management of these patients with mixed vasculogenic erectile dysfunction.

Administration, Oral↗