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Computed tomographic findings in akinetic mutism.

R S Young·K W Phelan·R A Lehman·J W Depenbusch·J Towfighi·W A Weidner
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Abstract

Brain-injured children who progress from coma to a sleeplike state of akinetic mutism are often misinterpreted by their parents as having improved. In children with akinetic mutism caused by extensive destruction of the cerebral gray matter, the computed tomographic scan may demonstrate the irreversible nature of the pathologic changes.

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Akinetic MutismBrainFemaleHumansInfantTomography, X-Ray ComputedCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

R S Young, K W Phelan, R A Lehman, J W Depenbusch, J Towfighi, W A Weidner. 1984. Computed tomographic findings in akinetic mutism.. https://doi.org/10.1001/archpedi.1984.02140400048011

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Akinetic Mutism↗
PubMed2006

[MM1 variant of sporadic Creutzfeldt-Jakob disease with long duration akinetic mutism state].

INTRODUCTION: When patients present with a characteristic clinical picture of Creutzfeldt-Jakob disease (CJD) associated with positive 14-3-3 assay, periodic sharp wave complexes, high-signal of the striatum on magnetic resonance imaging, and homozygosis methionine (M) in codon 129, the median survival is 4 to 6 months. CLINICAL CASE: We report a 58-year-old woman with these typical features who survived 21 months, 19 of them in an akinetic mutism state. The autopsy confirmed the diagnosis of the most common CJD phenotype (MM1), usually associated with a shorter survival, and demyleinitation of the white matter (panencephalopathic form). CONCLUSIONS: The MM1 variant of CJD, with a rapidly progressive course leading into an akinetic mutism shortly after disease onset can be followed by a long akinetic mutism state. This profile is suggestive of panencephalopathic form and should be taken into account when counselling about survival.

Akinetic Mutism↗