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Cell-substrate interaction. A method for evaluating the possible correlation between metastatic phenotype and cell surface energy.

S Reich·H Rosin·M Levy·R Karkash·A Raz
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Abstract

The interfacial energy of the non-attached to substrate cell surface was analysed in tumor cell variants of the K-1735 melanoma and UV-2237 fibrosarcoma series, which exhibit distinct metastatic phenotypes. The highly metastatic cell variants exhibited a two-fold increase in the ability to form rapid cell substrate interactions, as compared with their low-metastatic counterparts. These results further highlight the possible role of cell adhesiveness in the process of metastasis.

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AnimalsCell AdhesionCell LineFemaleFibrosarcomaMelanomaMiceMice, Inbred C3HNeoplasm MetastasisSurface PropertiesJournal ArticleResearch Support, Non-U.S. Gov't

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S Reich, H Rosin, M Levy, R Karkash, A Raz. 1984. Cell-substrate interaction. A method for evaluating the possible correlation between metastatic phenotype and cell surface energy.. https://doi.org/10.1016/0014-4827(84)90625-6

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