PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6762661

Augmentin: laboratory studies.

I D Farrell·P J Turner
View original source ↗Export metadata ↓

Abstract

Clavulanic acid is a beta-lactam antibiotic which, although it has little intrinsic activity, is a potent inhibitor of bacterial beta-lactamases. When combined with amoxycillin its range of activity includes penicillinase-producing strains of Staphylococcus aureus and many of the beta-lactamase-producing strains of Gram-negative bacilli. Bacteria sensitive to augmentin include amoxycillin-resistant strains of Haemophilus influenzae and Escherichia coli, in addition strains of Klebsiella aerogenes, Proteus mirabilis, Proteus vulgaris and Bacteroides fragilis are usually sensitive. The beta-lactamases produced by Enterobacter spp, Proteus morgani, Serratia marcescens and Pseudomonas aeruginosa are less susceptible to clavulanic acid and these bacteria are usually resistant to augmentin (1).

Explore related subjects

AmoxicillinAmoxicillin-Potassium Clavulanate CombinationAmpicillinBacteriaBacterial InfectionsDrug CombinationsEscherichia coliHumansJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

I D Farrell, P J Turner. 1982. Augmentin: laboratory studies.. https://doi.org/10.1177/00369330820270s105

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1999

[Antral biopsy is sufficient to confirm Helicobacter pylori eradication with the "new" one-week long triple treatments].

BACKGROUND: To evaluate whether antral biopsies are enough for confirming Helicobacter pylori eradication with the "new" one week triple therapies with omeprazole. PATIENTS AND METHODS: 229 duodenal ulcer patients were treated with omeprazole for 7 days plus two antibiotics. Eradication was confirmed with histology (two biopsies from both gastric antrum and body) and 13C-urea breath test one month after the end of therapy. RESULTS: H. pylori eradication was achieved in 76.9% of the patients (95% CI: 71-82%). Histology at antrum was highly reliable to detect eradication failure: in all but in one case in which H. pylori was observed at gastric body, was the microogranism also observed at antrum. Infection prevalences at both locations were not homogeneous (McNemar: 6.4; p < 0.05). Concordance between antral biopsies and breath test for H. pylori diagnosis after therapy was excellent (kappa: 0.91; SE: 0.07), and both prevalences were homogeneous (McNemar: 1.3; p > 0.05). CONCLUSIONS: Taking antral biopsies is enough for confirming H. pylori eradication with the "new" one week triple therapies.

Amoxicillin↗
PubMed1999

[Gastric MALT lymphoma, clinical features].

Gastric mucosa associated lymphoma (MALT) can be regarded as a pathogenetic continuum of reactive B lymphocyte accumulation due to Helicobacter pylori infection, which after a series of mutation may presumably transform into a low grade and later on into a high grade MALT lymphoma. If the lymphoma is confined to the mucosa or strictly to the superficial part of gastric wall, a conventional, regular Helicobacter pylori eradication procedure has a good chance to bring about clinical, histological and less frequently molecular biological remission as well.

Amoxicillin↗