Human and murine tumours: changes in cell surface structures coded by the major histocompatibility complex region.

S Ferrone; M A Pellegrino; G N Callahan

doi:10.1111/j.1744-313x.1980.tb00709.x

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Human and murine tumours: changes in cell surface structures coded by the major histocompatibility complex region.

S Ferrone·M A Pellegrino·G N Callahan

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Abstract

Serological and structural changes of surface markers involved in immune reactions may occur in human and murine tumour systems. Thus nine out of twenty-one human tumour cell lines and SV40-transformed fibroblasts differed from autologous lymphoblastoid cells or fibroblasts in their reactivity with HLA alloantisera. H-2 antigens isolated from the murine tumour cells 6C3HED and TP1422, undergo structural changes. An alien HLA-B7 was detected in sera from two melanoma patients. The serologic activity of H-2 antigens was significantly increased in the serum and ascites fluid of tumour bearing mice. Additionally, human SV40-transformed fibroblasts acquire receptors for monkey red blood cells and the murine lymphosarcoma cells 6C3HED express receptors for sheep red blood cells.

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Animals Cell Line Cell Membrane Fibroblasts Genetic Code H-2 Antigens Haplorhini Humans Lymphoma Major Histocompatibility Complex Melanoma Mice Rosette Formation Staphylococcal Protein A beta-Aminoethyl Isothiourea Journal Article Research Support, U.S. Gov't, P.H.S.

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S Ferrone, M A Pellegrino, G N Callahan. 1980. Human and murine tumours: changes in cell surface structures coded by the major histocompatibility complex region.. https://doi.org/10.1111/j.1744-313x.1980.tb00709.x

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