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PubMed · 6773002

Systemic disorders affecting the kidney.

R R Bailey
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Abstract

The renal lesion may be the most serious manifestation of a systemic disease. In the past six years 112 patients have had a renal biopsy as part of the evaluation of a systemic disorder. These patients are documented and some of the important observations highlighted. The greatest benefits have been in assessing the extent and severity of the renal involvement and using this information to make decisions regarding management and prognosis.

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BiopsyChildEpilepsy, Tonic-ClonicFemaleHumansKidneyKidney DiseasesLupus Erythematosus, SystemicNephritisPrognosisCase ReportsJournal Article

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BibTeXRIS

R R Bailey. 1980-06-25. Systemic disorders affecting the kidney.. https://pubmed.ncbi.nlm.nih.gov/6773002/

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[Rheumatoid arthritis, neutropenia and splenomegaly: the Felty syndrome].

HISTORY AND FINDINGS: A 59-year-old asymptomatic man, first diagnosed to have rheumatoid arthritis 27 years ago, was admitted to hospital because of splenomegaly and neutropenia, first noted 2 years ago. Physical examination confirmed splenomegaly and also revealed pretibial hyperpigmentation, but no evidence of active rheumatoid arthritis. EXAMINATIONS: Biochemical tests showed relative and absolute neutropenia (white blood cell count 2200/microliters; 1% neutrophils), thrombocytopenia and polyclonal hypergammaglobulinaemia. He also had increased erythrocyte sedimentation rate (38/92), a high titre of rheumatic factor (2128 IU/ml) and increased circulating immune-complexes (74%). Thoracic and abdominal computed tomography provided no evidence of malignant tumor. The spleen measured 15 x 7 x 10 cm. Bone-marrow biopsy from the iliac crest revealed abnormal maturation of granulopoiesis and marked lymphoid infiltration. The clinical triad of rheumatoid arthritis, splenomegaly and neutropenia are diagnostic of Felty's syndrome. As the patient was asymptomatic there was no indication for treatment. CONCLUSION: Felty's syndrome is a rare condition demanding considerable effort in differential diagnosis.

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