Flurazepam effects on methylphenidate-induced stereotyped behavior.

C Risch; D Kripke; D Janowsky

doi:10.1007/bf00432374

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Flurazepam effects on methylphenidate-induced stereotyped behavior.

C Risch·D Kripke·D Janowsky

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Abstract

The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of methylphenidate (25 mg/kg and 50 mg/kg) increased locomotion and sniffing behavior. Flurazepam 3.0 mg/kg augmented methylphenidate-induced stereotyped gnawing behavior and stereotypy. Flurazepam significantly decreased locomotion and sniffing, but did not interact with methylphenidate's effects on locomotion and sniffing.

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Animals Drug Synergism Flurazepam Humans Male Methylphenidate Mice Motor Activity Stereotyped Behavior Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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C Risch, D Kripke, D Janowsky. 1980. Flurazepam effects on methylphenidate-induced stereotyped behavior.. https://doi.org/10.1007/bf00432374

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