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PubMed · 6781552

[Decrease in the rats of intraliposomal proteolysis and labilization of rat liver lysosomes following suramin administration].

T A Korolenko·A B Pupyshev·A E Malygin
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Abstract

Suramin treatment (250 mg/kg bw) 24 and 48 h after administration is followed by the decreased rate of intralysosomal digestion of 14C-bovine albumin. Inhibition of proteolysis and lysosomal overloading with suramin cause the solubilization of acid hydrolases--beta-galactosidase, acid RNase, cathepsin D. There was a significant inhibition of acid phosphatase activity in the rat liver homogenate, suggesting that suramin might be used as a tool to study some features of lysosomal storage disease. Potential mechanisms of the decreased catabolic function of liver ribosomes during administration of lysosomal trophic drugs are discussed.

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Acid PhosphataseAnimalsCathepsinsLiverLysosomesMaleRatsRibonucleasesSerum Albumin, BovineSuraminbeta-GalactosidaseJournal Article

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T A Korolenko, A B Pupyshev, A E Malygin. 1980. [Decrease in the rats of intraliposomal proteolysis and labilization of rat liver lysosomes following suramin administration].. https://pubmed.ncbi.nlm.nih.gov/6781552/

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