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PubMed · 6798760

Prothrombin complex concentrates for clinical use.

S Chandra·H G Brummelhuis
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Abstract

Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A patients who develop factor VIII inhibitors is also described. The causes of and methods for the detection of potential thrombogenicity are discussed and suggestions which may result in a safer product are made.

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AnimalsBlood CoagulationBlood Coagulation FactorsDogsFactor IXFactor IXaFactor VIIIFactor XFactor XaHemophilia AHemophilia BHemostasisHepatitis BHepatitis CHumansPartial Thromboplastin TimeProthrombinQuality ControlRabbitsThrombin TimeTransfusion ReactionJournal ArticleReview

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S Chandra, H G Brummelhuis. Prothrombin complex concentrates for clinical use.. https://doi.org/10.1111/j.1423-0410.1981.tb01048.x

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