Bicarbonate concentrations in the renal cortex.

J L Gamble; A M Skoff

doi:10.1159/000172852

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PubMed · 6812181

Bicarbonate concentrations in the renal cortex.

J L Gamble·A M Skoff

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Abstract

Total CO2 (CO2+HCO3-) was measured in alkaline extracts of quickly frozen rat renal cortex. The mean concentration calculated for tissue water was 18.7 +/- SD 1.6 mEq/l (n = 10) when that measured in plasma water was 23.5 +/- 1.7. In other experiments (n = 6-10), the mean concentration in tissue water increased to 28.3 mEq/l after the animals were treated with benzolamide to inhibit carbonic anhydrase and to 38.1 mEq/l after they were infused with NaHCO3. On the other hand, the tissue concentration decreased to 14-15 mEq/l when they were hyperventilated or infused with HCl. Calculations based on published micropuncture data indicate that the usual intracellular concentration is 20-25 mEq/l or about twice that usually reported for skeletal muscle; and in contrast to muscle, the findings are suggestive of large variations in metabolic disorders.

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Acidosis, Respiratory Animals Benzolamide Bicarbonates Carbon Dioxide Female Hydrogen-Ion Concentration Hyperventilation Kidney Cortex Rats Rats, Inbred Strains Stroke Volume Thiadiazoles Journal Article

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J L Gamble, A M Skoff. 1982. Bicarbonate concentrations in the renal cortex.. https://doi.org/10.1159/000172852

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