Warthin's tumor.

T Miksanek; C V Reyes; R Borkenhagen

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PubMed · 6829386

Warthin's tumor.

T Miksanek·C V Reyes·R Borkenhagen

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Abstract

Warthin's tumor is a benign neoplasm that most often arises in the parotid gland. The lesion is often clinically silent, but various radiographic studies are useful in establishing the diagnosis. Surgical resection generally results in a complete cure. The diagnosis of Warthin's tumor should be considered in any patient who presents with a mass lesion in the area of the parotid gland.

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T Miksanek, C V Reyes, R Borkenhagen. 1983. Warthin's tumor.. https://pubmed.ncbi.nlm.nih.gov/6829386/

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Evidence of lymphangiogenesis in Warthin's tumor of the parotid gland.

The details of the pathogenesis of cystadenolymphoma (Warthin's tumor) of the parotid gland are still unclear. Neovascularization is considered to be a pivotal factor for solid tumor progression and biological behavior of the tumor. Using double-labeling immunohistochemistry for LYVE-1 and CD34 (specific markers for lymphatic and vascular endothelial cells, respectively) this study analyzes lymphatic vessel density (LVD) and blood vessel density (BVD) in 10 Warthin's tumors and 10 pleomorphic adenomas of the parotid gland as well as in 5 normal parotid glands and 5 normal parotid lymph nodes. There was no significant difference in the intratumoral LVD and BVD among pleomorphic adenoma and normal parotid gland tissue. In contrast, the intratumoral LVD and BVD were significantly higher in Warthin's tumor than pleomorphic adenoma, normal parotid gland and parotid lymph node (P<0.0001 versus P<0.004). The increase in lymphatic vessels in Warthin's tumor suggests that epithelial tumor cells might promote lymphangiogenesis in this kind of lesions.

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