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Localization of membrane-bound catechol-O-methyltransferase.

A J Rivett·A Francis·J A Roth
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Abstract

Previous studies of the distribution of catechol-O-methyltransferase (COMT) have concentrated on the soluble enzyme activity. In this study the activity of the membrane-bound enzyme was determined in different brain regions and peripheral tissues of the rat. Membrane-bound COMT, like the soluble enzyme, has a general distribution with high levels in liver, kidney, and vas deferens. However, the ratio of membrane-bound to soluble activity varies almost 30-fold in different tissues, with the highest ratio in brain. Membrane-bound activity varies twofold within brain. In view of their different localization and kinetic properties, it seems likely that the two forms of COMT have different functions in vivo.

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AnimalsBrainCatechol O-MethyltransferaseCell MembraneKidneyKineticsLiverMaleOrgan SpecificityRatsRats, Inbred StrainsVas DeferensJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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A J Rivett, A Francis, J A Roth. 1983. Localization of membrane-bound catechol-O-methyltransferase.. https://doi.org/10.1111/j.1471-4159.1983.tb13597.x

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