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Failure of various agents to decrease oleic acid pulmonary albumin leak.

H J Sugerman·C R Blocher·J I Hirsch·A M Strash·J L Tatum
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Abstract

Computerized pulmonary gamma scintigraphy has been shown to be a sensitive technique for the measurement of albumin flux in oleic acid pulmonary microvascular injury. In this technique technetium-99m-tagged human serum albumin is administered intravenously and lung:heart radioactivity ratios are constructed. This ratio remains constant unless there is a net flux of albumin from the vascular space into the lung, when a rising ratio is seen, called the "slope of injury" or SI. Gamma scintigraphy provides a method to rapidly screen the ability of various possible therapeutic agents to reduce the flux of albumin in experimental ARDS. In this study, 0.05 ml/kg oleic acid produced a significant increase in the SI. None of the agents tested (30 mg/kg methylprednisolone, 12.5 mg/kg ibuprofen, 4 mg/kg MK-447, a superoxide radical scavenger, or 140 mg/kg calcium gluconate) were able to alter the scintigraphically measured increased albumin flux produced by 0.05 ml/kg oleic acid.

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AlbuminsAnimalsButylated HydroxytolueneCalcium GluconateDogsIbuprofenLungMethylprednisoloneOleic AcidOleic AcidsRadionuclide ImagingJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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H J Sugerman, C R Blocher, J I Hirsch, A M Strash, J L Tatum. 1983. Failure of various agents to decrease oleic acid pulmonary albumin leak.. https://doi.org/10.1016/0022-4804(83)90096-3

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