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PubMed · 6897531

A numerical method for biphasic curve fitting with a programmable calculator.

D Ristanović·J Malesević·B Milutinović
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Abstract

Elimination kinetics of bromsulphalein (BSP) after a single injection into the circulation of rats were examined by means of a four-compartment model. BSP plasma concentrations were measured colorimetrically. A program written for the Texas Instruments TI-59 programmable calculator is presented, which will calculate the fractional blood clearance of BSP using an iteration procedure. A simple method of fitting biphasic decay curves to experimental data is also proposed.

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AnimalsComputersKineticsMetabolic Clearance RateModels, BiologicalRatsRats, Inbred StrainsSoftwareStatistics as TopicSulfobromophthaleinComparative StudyJournal Article

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D Ristanović, J Malesević, B Milutinović. 1982. A numerical method for biphasic curve fitting with a programmable calculator.. https://doi.org/10.1016/0010-4825(82)90037-3

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